Synthesis and Antifungal Activity of Carabrone Derivatives

Molecules

Jun-Tao Feng¹  Zhi-Qing Ma¹  Jiang-Hua Li¹  Jun He¹  Hui Xu¹ 

[1] ¹Research and Development Center of Biorational Pesticide, College of Plant Protection, Northwest A&F University, Yangling 712100, China ²Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University,Yangling 712100, China

关键词: carabrone;    structural modification;    synthesis;    antifungal activity;   

DOI  :  10.3390/molecules15096485

来源: mdpi

【 摘 要 】

Nine derivatives 6-14 of carabrone (1) were synthesized and tested in vitro against Colletotrichum lagenarium Ell et Halst using the spore germination method. Among all of the derivatives, compounds 6-8 and 12 showed more potent antifungal activity than 1. Structure-activity relationships (SAR) demonstrated that the γ-lactone was necessary for the antifungal activity of 1, and the substituents on the C-4 position of 1 could significantly affect the antifungal activity.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.