Synthesis, Antifungal Activities and Qualitative Structure Activity Relationship of Carabrone Hydrazone Derivatives as Potential Antifungal Agents

International Journal of Molecular Sciences

Hao Wang²  Shuang-Xi Ren²  Ze-Yu He²  De-Long Wang²  Xiao-Nan Yan²  Jun-Tao Feng¹ 

[1] Research & Development Center of Biorational Pesticide, Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, Northwest A&F University, Xinong Road 22, Yangling 712100, Shaanxi, China;

关键词: carabrone;    hydrazone derivatives;    chemical modification;    antifungal activity;    structure-activity relationship;   

DOI  :  10.3390/ijms15034257

来源: mdpi

【 摘 要 】

Aimed at developing novel fungicides for relieving the ever-increasing pressure of agricultural production caused by phytopathogenic fungi, 28 new hydrazone derivatives of carabrone, a natural bioactive sesquisterpene, in three types were designed, synthesized and their antifungal activities against Botrytis cinerea and Colletotrichum lagenarium were evaluated. The result revealed that all the derivatives synthesized exhibited considerable antifungal activities in vitro and in vivo, which led to the improved activities for carabrone and its analogues and further confirmed their potential as antifungal agents.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland