Effect of the Glycemic Index of Carbohydrates on Acne vulgaris

Nutrients

Rebecca C. Reynolds²  Stephen Lee³  James Y. J. Choi³  Fiona S. Atkinson²  Karola S. Stockmann²  Peter Petocz¹ 

[1] Department of Statistics, Macquarie University, NSW 2109, Australia;Human Nutrition Unit, School of Molecular Bioscience G08, The University of Sydney, NSW 2006, Australia;Department of Dermatology, Concord Repatriation General Hospital, The University of Sydney, NSW 2006, Australia;

关键词: glycemic index;    carbohydrate;    diet;    acne vulgaris;    adolescent males;   

DOI  :  10.3390/nu2101060

来源: mdpi

【 摘 要 】

Acne vulgaris may be improved by dietary factors that increase insulin sensitivity. We hypothesized that a low-glycemic index diet would improve facial acne severity and insulin sensitivity. Fifty-eight adolescent males (mean age ± standard deviation 16.5 ± 1.0 y and body mass index 23.1 ± 3.5 kg/m²) were alternately allocated to high or low glycemic index diets. Severity of inflammatory lesions on the face, insulin sensitivity (homeostasis modeling assessment of insulin resistance), androgens and insulin-like growth factor-1 and its binding proteins were assessed at baseline and at eight weeks, a period corresponding to the school term. Forty-three subjects (n = 23 low glycemic index and n = 20 high glycemic index) completed the study. Diets differed significantly in glycemic index (mean ± standard error of the mean, low glycemic index 51 ± 1 vs. high glycemic index 61 ± 2, p = 0.0002), but not in macronutrient distribution or fiber content. Facial acne improved on both diets (low glycemic index −26 ± 6%, p = 0.0004 and high glycemic index −16 ± 7%, p = 0.01), but differences between diets did not reach significance. Change in insulin sensitivity was not different between diets (low glycemic index 0.2 ± 0.1 and high glycemic index 0.1 ± 0.1, p = 0.60) and did not correlate with change in acne severity (Pearson correlation r = −0.196, p = 0.244). Longer time frames, greater reductions in glycemic load or/and weight loss may be necessary to detect improvements in acne among adolescent boys.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland