Synthesis of Novel 1-[(2,6-Dichloro-4-trifluoromethyl)phenyl]-3-aryl-1H-pyrazole-4-carbaldehydes

Molecules

Huanan Hu¹  Changhua Ge¹  Lisheng Ding¹ 

[1] ¹College of Pharmaceutical and Chemical Engineering, Taizhou University, Linhai 317000, China ²Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China ³Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences, Ningbo 315211, China

关键词: Vilsmeier-Haack reagent;    phenylhydrazine;    phenylhydrazone;    1H-pyrazole-4-carbaldehyde;   

DOI  :  10.3390/molecules15107472

来源: mdpi

【 摘 要 】

A series of novel 1-[(2,6-dichloro-4-trifluoromethyl)phenyl]-3-aryl-1H-pyrazole-4-carbaldehydes 6a-i were synthesized using the Vilsmeier-Haack reagent. The structures of all the title compounds have been confirmed by elemental analysis, ¹H-NMR and ¹³C-NMR and in addition, the structure of intermediate 5b was investigated by X-ray crystallography.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.