2-{(E)-2-[(3E)-2-Chloro-3-{(2E)-2-[1,1-dimethyl-3-(3-phenylpropyl)-1,3-dihydro-2H-benzo[e]indol-2-ylidene]-ethylidene}cyclohex-1-en-1-yl]ethenyl}-1,1-dimethyl-3-(3-phenylpropyl)-1H-benzo[e]indolium Iodide

Molbank

Eric A. Owens¹  Joseph G. Tawney¹ 

[1] ¹Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA ²Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA ³Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA 30303, USA

关键词: Hydrophobicity;    carbocyanine;    near-infrared;    fluorescence;    absorption;    Vilsmeier-Haack reagent;   

DOI  :  10.3390/M814

来源: mdpi

【 摘 要 】

In four synthetic steps we successfully prepared a red-shifted heptamethine cyanine dye (λ_max = 825 nm in methanol) that could be very useful for biochemists and bioanalytical chemists for probing lipophilic environments, including the hydrophobic pockets of enzymes. The heptamethine dye structure was characterized by various spectroscopic techniques including ¹H-NMR, ¹³C-NMR and high-resolution accurate mass spectroscopy (HRMS). We have also shown the hydrophobicity spectrally by varying methanol/water ratios and observing corresponding absorbance and fluorescencespectral changes.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.