Role of Cell Division Autoantigen 1 (CDA1) in Cell Proliferation and Fibrosis

Genes

Ban-Hock Toh¹  Yugang Tu²  Zemin Cao²  Mark E. Cooper² 

[1] Autoimmunity Laboratory, Centre for Inflammatory Diseases, Department of Medicine, Faculty of Medicine, Nursing, Health Sciences, Monash University, Clayton, Victoria 3168, Australia;Diabetes, Metabolism Division, Baker IDI Heart, Diabetes Institute, 75 Commercial Rd, Melbourne, Victoria 3004, Australia; E-Mails:

关键词: TGF-β;    tumorigenesis;    DNA damage;    atherosclerosis;    diabetes mellitus;   

DOI  :  10.3390/genes1030335

来源: mdpi

【 摘 要 】

Cell Division Autoantigen 1 (CDA1) was discovered following screening a human expression library with serum from a patient with Discoid Lupus Erythematosus. CDA1, encoded by TSPYL2 on the X chromosome, shares anti-proliferative, pro‑fibrotic properties with TGF-β. It inhibits cell growth through p53, pERK1/2, p21‑mediated pathways, is implicated in tumorigenesis, the DNA damage response. Its pro-fibrotic property is mediated through cross-talk with TGF-β that results in upregulation of extracellular matrix proteins. The latter properties have identified a key role for CDA1 in diabetes associated atherosclerosis. These dual properties place CDA1 as an attractive molecular target for treating tumors, vascular fibrosis including atherosclerosis, other vascular disorders associated with enhanced TGF-β action, tissue scarring.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland