New Anti-Inflammatory and Anti-Proliferative Constituents from Fermented Red Mold Rice Monascus purpureus NTU 568

Molecules

Ya-Wen Hsu¹  Li-Chuan Hsu¹  Chao-Lin Chang¹  Yu-Han Liang¹  Yao-Haur Kuo¹ 

[1] ¹Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan 10617, Taiwan ²Division of Herbal Drugs and Natural Products, National Research Institute of Chinese Medicine, Taipei, Taiwan 11221, Taiwan ³Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan 40402, Taiwan

关键词: red mold rice (RMR);    Monascus purpureus NTU 568;    azaphilonoid derivatives;    anti-inflammatory;    anti-proliferativered mold rice (RMR);    Monascus purpureus NTU 568;    azaphilonoid derivatives;    anti-inflammatory;    anti-proliferative;   

DOI  :  10.3390/molecules15117815

来源: mdpi

【 摘 要 】

Six azaphilonoid derivatives, including two new blue fluorescent monapurfluores A (1) and B (2), two known pyridine-containing molecules, monascopyridines C (3) and D (4), and two known monasfluores A (5) and B (6), were isolated and characterized from red mold rice fermented by Monascus purpureus NTU 568. Structural elucidation of new isolates was based on nuclear magnetic resonance (¹H- NMR, ¹³C-NMR, COSY, HMQC, and HMBC) and other spectroscopic analyses. Bioactivity evaluation indicated that 1-6 possessed anti-inflammatory activities with dose-dependent relationships for lipopolysaccharide (LPS)-induced nitric oxide production. Furthermore, 1-4 also showed moderate antiproliferative effects against human laryngeal carcinoma (HEp-2) (IC₅₀ = 14.81~20.06 μg/mL) and human colon adenocarcinoma (WiDr) (IC₅₀ = 12.89~21.14 μg/mL).

【 授权许可】

CC BY   
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