Cladielloides A and B: New Eunicellin-Type Diterpenoids from an Indonesian Octocoral Cladiella sp.

Marine Drugs

Yung-Husan Chen¹  Chia-Ying Tai¹  Tsong-Long Hwang²  Ching-Feng Weng⁴  Jan-Jung Li¹  Lee-Shing Fang⁵  Wei-Hsien Wang¹  Yang-Chang Wu³ 

[1] National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan; E-Mails:;Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan; E-Mail:;Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan;Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan; E-Mail:;Department of Sport, Health, and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan; E-Mail:

关键词: cladielloide;    eunicellin;    octocoral;    cytotoxicity;    superoxide anion;    elastase;   

DOI  :  10.3390/md8122936

来源: mdpi

【 摘 要 】

Two new eunicellin-type diterpenoids, cladielloides A (1) and B (2), which were found to possess a 2-hydroxybutyroxy group in their structures, were isolated from an Indonesian octocoral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods. Cladielloide B (2) exhibited moderate cytotoxicity toward CCRF-CEM tumor cells and this compound displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland