Discovery of New Eunicellins from an Indonesian Octocoral Cladiella sp.

Marine Drugs

Yung-Husan Chen¹  Chia-Ying Tai¹  Yin-Di Su¹  Yu-Chia Chang¹  Mei-Chin Lu¹  Ching-Feng Weng⁴  Jui-Hsin Su¹  Tsong-Long Hwang²  Yang-Chang Wu³ 

[1] National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan; E-Mails:;Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan; E-Mail:;Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan;Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan; E-Mail:

关键词: cladieunicellin;    eunicellin;    octocoral;    Cladiella;    superoxide anion;    elastase;   

DOI  :  10.3390/md9060934

来源: mdpi

【 摘 要 】

Two new 11-hydroxyeunicellin diterpenoids, cladieunicellin F (1) and (–)-solenopodin C (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods, and eunicellin 2 was found to be an enantiomer of the known eunicellin solenopodin C (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils. The previously reported structures of two eunicellin-based compounds, cladielloides A and B, are corrected in this study.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.