Cladieunicellins M–Q, New Eunicellins from Cladiella sp.

Marine Drugs

Tsung-Hung Chen²  Wu-Fu Chen³  Zhi-Hong Wen¹  Mei-Chin Lu²  Wei-Hsien Wang⁵  Jan-Jung Li⁵  Yang-Chang Wu⁴ 

[1] Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan; E-Mail:;Graduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan; E-Mails:;Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan; E-Mail:;School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan;National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan; E-Mails:

关键词: eunicellin;    Cladiella;    cladieunicellin;    cytotoxicity;   

DOI  :  10.3390/md12042144

来源: mdpi

【 摘 要 】

Five new 7α-hydroxyeunicellin-based diterpenoids, designated as cladieunicellins M–Q (1–5), were isolated from a Formosan octocoral Cladiella sp. The structures of 1–5 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxicity of metabolites 1–5 against the human leukemia Molt 4 and HL 60 is also described. Among them, compounds 1, 3 and 5 exhibited moderate cytotoxicity toward Molt 4 cells with IC₅₀ values 16.43, 14.17 and 15.55 μM, respectively. Preliminary SAR (structure activity relationship) information was obtained from these compounds and their analogues.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.