A Mangifera indica L. Extract Could Be Used to Treat Neuropathic Pain and Implication of Mangiferin

Molecules

Bárbara B. Garrido-Suárez¹  Gabino Garrido¹  Rene Delgado¹  Fe Bosch¹ 

[1] ¹Laboratorio de Farmacología Molecular del Centro de Investigación y Desarrollo de Medicamentos, Ave. 26 No. 1605, Nuevo Vedado, Havana, Cuba

关键词: neuropathic pain;    neuroimmune mechanisms;    Vimang;    Mangifera indica L.;    mangiferin;   

DOI  :  10.3390/molecules15129035

来源: mdpi

【 摘 要 】

It has been accepted that neuroinflammation, oxidative stress and glial activation are involved in the central sensitization underlying neuropathic pain. Vimang is an aqueous extract of Mangifera indica L. traditionally used in Cuba for its analgesic, anti-inflammatory, antioxidant and immunomodulatory properties. Several formulations are available, and also for mangiferin, its major component. Preclinical studies demonstrated that these products prevented tumor necrosis factor α -induced IκB degradation and the binding of nuclear factor κB to DNA, which induces the transcription of genes implicated in the expression of some mediators and enzymes involved in inflammation, pain, oxidative stress and synaptic plasticity. In this paper we propose its potential utility in the neuropathic pain treatment. This hypothesis is supported in the cumulus of preclinical and clinical evidence around the extract and mangiferin, its major component, and speculates about the possible mechanism of action according to recent advances in the physiopathology of neuropathic pain.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.