Report of cases in patients with acute herpetic neuralgia using a Mangifera indica extract

Revista Brasileira de Farmacognosia

Garrido-Suárez, Beatriz¹  Hospital Docente Clínico Quirúrgico 10 de Octubre, Cuba¹  Centro de Investigación y Desarrollo de Medicamentos, Cuba¹  Universidad Católica del Norte, Chile¹  Garrido, Gabino¹  Delgado, Rene¹  Bosch, Fe¹  Hernández, Camilo E.¹  Rabí, María del C.¹ 

关键词: herpes zoster;    Mangifera indica L.;    neuropathic pain;    post-herpetic neuralgia;    Vimang;   

DOI  :  10.1590/S0102-695X2011005000125

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

It has been accepted that neuroinflammation, oxidative stress and glial activation are involved in the central sensitization underlying neuropathic and inflammatory pain. Vimang® is the brand name of an aqueous extract of Mangifera indica L., Anacardiaceae, traditionally used in Cuba for its antioxidant, antiinflammatory, analgesic, and immunomodulatory properties. In the present study, we determined the possible effects of Vimang formulations in acute herpes zoster (n=12) patients, that received a daily dose of 1800 mg of extract (two coated Vimang tablets, 300 mg each, three times daily before meals) associated to low doses of amitriptyline (10-25 mg/d). In addition to the tablets, they utilized compresses containing Vimang dissolution at 2% on skin lesions for thirty days. The average daily pain score using a Likert scale and variations in concomitant drug daily dosage were determined. The analgesic effect was observed from week 1 (p<0.001) with respect to baseline data and none showed post-herpetic neuralgia. Significant reduction of antidepressant medication (p<0.01) and analgesic rescue dosages (p=0.0035) with respect to the initial daily dosage were showed. No adverse events were reported. The results obtained in this report of cases suggest that Vimang supplementation might be beneficial to prevent and treat neuropathic pain.

【 授权许可】

Unknown