Experimental Models for Assaying Microvascular Endothelial Cell Pathophysiology in Stroke

Molecules

Susanna Camós¹ 

[1] Department of Neurology, Girona Biomedical Research Institute (IdIBGi), Dr. Josep Trueta University Hospital, Av de França s/n, 17007 Girona, Spain

关键词: neuroprotection;    blood brain barrier;    brain endothelial cells;    cerebral ischaemia;    angiogenesis;   

DOI  :  10.3390/molecules15129104

来源: mdpi

【 摘 要 】

It is important to understand the molecular mechanisms underlying neuron death following stroke in order to develop effective neuroprotective strategies. Since studies on human stroke are extremely limited due to the difficulty in collecting post-mortem tissue at different time points after the onset of stroke, brain ischaemia research focuses on information derived from in-vitro models of neuronal death through ischaemic injury [1]. This review aims to provide an update on the different in-vitro stroke models with brain microvascular endothelial cells that are currently being used. These models provide a physiologically relevant tool to screen potential neuroprotective drugs in stroke and to study the molecular mechanisms involved in brain ischaemia.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.