Sonogashira Reaction of Aryl and Heteroaryl Halides with Terminal Alkynes Catalyzed by a Highly Efficient and Recyclable Nanosized MCM-41 Anchored Palladium Bipyridyl Complex

Molecules

Bo-Nan Lin¹  Shao-Hsien Huang¹  Wei-Yi Wu¹  Chung-Yuan Mou¹ 

[1] ¹Institute of Organic and Polymeric Materials, National Taipei University of Technology, Taipei 106, Taiwan ²Department of Chemistry, National Taiwan University, Taipei 106, Taiwan

关键词: Sonogashira reaction;    mesoporous silica;    palladium complex;    recyclable catalyst;    heterogeneous catalysis;   

DOI  :  10.3390/molecules15129157

来源: mdpi

【 摘 要 】

A heterogeneous catalyst, nanosized MCM-41-Pd, was used to catalyze the Sonogashira coupling of aryl and heteroaryl halides with terminal alkynes in the presence of CuI and triphenylphosphine. The coupling products were obtained in high yields using low Pd loadings to 0.01 mol%, and the nanosized MCM-41-Pd catalyst was recovered by centrifugation of the reaction solution and re-used in further runs without significant loss of reactivity.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.