Cancer Stem Cells in Head and Neck Cancer

Cancers

Doyel Mitra²  Stephen P. Malkoski¹ 

[1] Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, Aurora CO, 80045, USA; E-Mail:;Department of Pathology, University of Colorado Denver, AMC 12800 E. 19^th Ave., Aurora CO, 80045, USA; E-Mail:

关键词: chemoresistance;    radioresistance;    transplantation;    tumorigenicity;   

DOI  :  10.3390/cancers3010415

来源: mdpi

【 摘 要 】

Head and neck cancer (HNC) is the sixth most common malignancy world-wide, however the survival rate has not improved for the past 20 years. In recent years, the cancer stem cell (CSC) hypothesis has gained ground in several malignancies and there is mounting evidence suggesting CSCs mediate tumor resistance to chemotherapy and radiation therapy. However, the CSC theory is also challenged at least in certain types of cancer. Here we review the progress of CSC studies in HNC, which suggest that HNC conforms to the CSC model. The identified CSC markers and their tumor initiation properties provide a framework for the development of novel therapeutic strategies for HNC.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.