A Quest for Initiating Cells of Head and Neck Cancer and Their Treatment

Cancers

Chao Chen¹  Beate Krle²  Andreas M. Kaufmann³ 

[1] Department of Otolaryngology and Head and Neck Surgery Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany;Institute of Toxicology, University Medical Center, Mainz, Germany; E-Mail:;Clinic for Gynecology, Charité-Universitätsmedizin Berlin, Berlin, Germany; E-Mail:

关键词: metastasis;    stemness;    ALDH1;    Sox2;    Nanog;    Oct3/4;    human papillomavirus;    immunotherapy;    chemoresistance;    radioresistance;    epithelial mesenchymal transition;   

DOI  :  10.3390/cancers2031528

来源: mdpi

【 摘 要 】

The biology of head and neck squamous cell carcinomas (HNSCC) and other cancers have been related to cancer stem-like cells (CSC). Specific markers, which vary considerably depending on tumor type or tissue of origin, characterize CSC. CSC are cancer initiating, sustaining and mostly quiescent. Compared to bulk tumors, CSC are less sensitive to chemo- and radiotherapy and may have low immunogenicity. Therapeutic targeting of CSC may improve clinical outcome. HNSCC has two main etiologies: human papillomavirus, a virus infecting epithelial stem cells, and tobacco and alcohol abuse. Here, current knowledge of HNSCC-CSC biology is reviewed and parallels to CSC of other origin are drawn where necessary for a comprehensive picture.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland.