Pharmaceuticals | |
Pharmacological Evaluation of 3-Carbomethoxy Fentanyl in Mice | |
Sonja Vuckovic1  Milica Prostran1  Milovan Ivanovic2  Ljiljana Dosen-Micovic2  Katarina Savic Vujovic1  Cedomir Vucetic3  Marko Kadija3  | |
[1] Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, P.O. Box 38, 11129, Belgrade, Serbia;Faculty of Chemistry, University of Belgrade, Belgrade, Serbia;Institute for Orthopaedic Surgery and Traumatology, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia | |
关键词: fentanyl; 3-carbomethoxy fentanyl; hot plate; rotarod; acute toxicity; mice; | |
DOI : 10.3390/ph4020233 | |
来源: mdpi | |
【 摘 要 】
In many animal species, as well as in humans, high doses of fentanyl (F) produce marked neurotoxic effects, such as muscular rigidity and respiratory depression. The antinociception (hot-plate test), impairment of motor coordination (rotarod test) and acute toxicity of intraperitoneal newly synthesized analogs, (±)
【 授权许可】
CC BY
© 2011 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190050964ZK.pdf | 172KB | download |