Journal of Pharmacological Sciences | |
Evaluation of Anxiolytic-like Effects of Some Short-Acting Benzodiazepine Hypnotics in Mice | |
Kenshi Takechi1  Tomomi Nishino1  Tomoko Takeuchi1  Chiaki Kamei1  | |
[1] Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan | |
关键词: benzodiazepine; anxiolytic-like effect; hypnotics; plus maze; rotarod; | |
DOI : 10.1254/jphs.08107FP | |
学科分类:药学 | |
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society | |
【 摘 要 】
References(17)Cited-By(12)Anxiolytic-like effects of some short-acting benzodiazepine hypnotics were examined with experimental paradigms of anxiety using an elevated plus-maze in male ICR mice. Diazepam was used as a positive control. The drug at a dose of 1 mg/kg significantly increased the percentage of time spent in the open arms and percentage of the number of open arm entries in the elevated plus-maze. Triazolam, brotizolam, rilmazafone, and lormetazepam also showed an anxiolytic-like effect as indicated by the significant increase in the percentage of time spent in the open arms and percentage of the number of open arm entries. Effects of short-acting benzodiazepine hypnotics used in the study were more potent than those of diazepam. In addition, the doses affecting the elevated plus-maze by benzodiazepine hypnotics were much smaller than those that showed muscle-relaxant activity measured by the rotarod test, indicating that anxiolytic-like effects of benzodiazepine hypnotics had high specificity and selectivity.
【 授权许可】
Unknown
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