Cell Surface Markers in Colorectal Cancer Prognosis

International Journal of Molecular Sciences

Larissa Belov¹  Jerry Zhou² 

[1] School of Molecular Bioscience, University of Sydney, Sydney, NSW 2006, Australia;

关键词: colorectal cancer;    biomarkers;    proteomics;    prognostic;   

DOI  :  10.3390/ijms12010078

来源: mdpi

【 摘 要 】

The classification of colorectal cancers (CRC) is currently based largely on histologically determined tumour characteristics, such as differentiation status and tumour stage, i.e., depth of tumour invasion, involvement of regional lymph nodes and the occurrence of metastatic spread to other organs. These are the conventional prognostic factors for patient survival and often determine the requirement for adjuvant therapy after surgical resection of the primary tumour. However, patients with the same CRC stage can have very different disease-related outcomes. For some, surgical removal of early-stage tumours leads to full recovery, while for others, disease recurrence and metastasis may occur regardless of adjuvant therapy. It is therefore important to understand the molecular processes that lead to disease progression and metastasis and to find more reliable prognostic markers and novel targets for therapy. This review focuses on cell surface proteins that correlate with tumour progression, metastasis and patient outcome, and discusses some of the challenges in finding prognostic protein markers in CRC.

【 授权许可】

CC BY   
© 2011 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.