Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity

Molecules

Marco Martín González-Chávez¹  Francisco Méndez¹  Roberto Martínez¹  Cuaúhtemoc Pérez-González¹ 

[1] ¹Programa de Doctorado en Ciencias Biológicas, Universidad Autónoma Metropolitana, México D.F., Mexico

关键词: benzimidazole;    sulphonamide;    MRSA;    antibacterial activity;   

DOI  :  10.3390/molecules16010175

来源: mdpi

【 摘 要 】

A series of benzimidazolylbenzenesulfonamide compounds containing electron-releasing and electron-withdrawing substituents were synthesized and tested for their in vitro antibacterial activity. Two BZS compounds showed strong antibacterial activity against methicillin-resistant Staphylococcus aureus and Bacillus subtilis. Quantitative studies of their structure-activity relationship using a simple linear regression analysis were applied to explore the correlation between the biological activity and the charges on acidic hydrogen atoms in the synthesized compounds.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.