Hes1 Oscillations Contribute to Heterogeneous Differentiation Responses in Embryonic Stem Cells

Genes

Taeko Kobayashi¹ 

[1] Institute for Virus Research, Kyoto University, Shogoin-Kawahara, Sakyo-ku, Kyoto 606-8507, Japan; E-Mail:

关键词: ES cell;    heterogeneity;    differentiation;    Hes1;    oscillation;   

DOI  :  10.3390/genes2010219

来源: mdpi

【 摘 要 】

Embryonic stem (ES) cells can differentiate into multiple types of cells belonging to all three germ layers. Although ES cells are clonally established, they display heterogeneous responses upon the induction of differentiation, resulting in a mixture of various types of differentiated cells. Our recent reports have shown that Hes1 regulates the fate choice of ES cells by repressing Notch signaling, and that the oscillatory expression of Hes1 contributes to various differentiation responses in ES cells. Here we discuss the mechanism regulating the intracellular dynamics in ES cells and how to trigger the lineage choice from pluripotent ES cells.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.