Cytotoxic and Antimicrobial Activity of Pseudopterosins and seco-Pseudopterosins Isolated from the Octocoral Pseudopterogorgia elisabethae of San Andrés and Providencia Islands (Southwest Caribbean Sea)

Marine Drugs

Hebelin Correa²  Fabio Aristizabal¹  Carmenza Duque² 

[1] Departamento de Farmacia, Universidad Nacional de Colombia, Cra. 30 N° 45-03, Bogotá D.C., Colombia; E-Mail:;Departamento de Química, Universidad Nacional de Colombia, Cra. 30 N° 45-03, Bogotá D.C., Colombia; E-Mail:

关键词: marine natural products;    pseudopterosins;    seco-pseudopterosins;    Pseudopterogorgia elisabethae;    cytotoxic activity;    antimicrobial activity;   

DOI  :  10.3390/md9030334

来源: mdpi

【 摘 要 】

To expand the potential of pseudopterosins and seco-pseudopterosins isolated from the octocoral Pseudopterogorgia elisabethae of San Andrés and Providencia islands (southwest Caribbean Sea), we report the anti-microbial profile against four pathogenic microorganisms (Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa and Candida albicans) and report a more complete cytotoxic profile against five human cells lines (HeLa, PC-3, HCT116, MCF-7 and BJ) for the compounds PsG, PsP, PsQ, PsS, PsT, PsU, 3-O-acetyl-PsU, seco-PsJ, seco-PsK and IMNGD. For the cytotoxic profiles, all compounds evaluated showed moderate and non-selective activity against both tumor and normal cell lines, where PsQ and PsG were the most active compounds (GI₅₀ values between 5.8 μM to 12.0 μM). With respect to their anti-microbial activity the compounds showed good and selective activity against the Gram-positive bacteria, while they did not show activity against the Gram-negative bacterium or yeast. PsU, PsQ, PsS, seco-PsK and PsG were the most active compounds (IC₅₀ 2.9–4.5 μM) against S. aureus and PsG, PsU and seco-PsK showed good activity (IC₅₀ 3.1–3.8 μM) against E. faecalis, comparable to the reference drug vancomycin (4.2 μM).

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.