Cancer Stem Cell Radioresistance and Enrichment: Where Frontline Radiation Therapy May Fail in Lung and Esophageal Cancers

Cancers

Giang Huong Nguyen¹  Mandi M. Murph² 

[1] Balliol College, University of Oxford, Oxford, UK; E-Mail:;Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia 30602, USA; E-Mail:

关键词: cancer stem cells;    lung cancer;    esophageal cancer;    radiation therapy;   

DOI  :  10.3390/cancers3011232

来源: mdpi

【 摘 要 】

Many studies have highlighted the role cancer stem cells (CSC) play in the development and progression of various types of cancer including lung and esophageal cancer. More recently, it has been proposed that the presence of CSCs affects treatment efficacy and patient prognosis. In reviewing this new area of cancer biology, we will give an overview of the current literature regarding lung and esophageal CSCs and radioresistance of CSC, and discuss the potential therapeutic applications of these findings.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.