Allobetulin and Its Derivatives: Synthesis and Biological Activity

Molecules

Wim Dehaen¹  Anastassiya A. Mashentseva¹ 

[1] ¹Molecular Design and Synthesis, Department of Chemistry, University of Leuven, Celestijnenlaan 200F, 3-3001 Leuven, Belgium ²Department of Chemistry, The L.N.Gumilev Eurasian National University, Munaitpasov str. 5, 010008 Astana, Kazakhstan ³Department of Biochemistry, Medical University “Astana”, Beybetshilyk. 51, 010000 Astana, Kazakhstan

关键词: triterpene;    allobetulin;    rearrangement;    biological activity;   

DOI  :  10.3390/molecules16032443

来源: mdpi

【 摘 要 】

This review covers the chemistry of allobetulin analogs, including their formation by rearrangement from betulin derivatives, their further derivatisation, their fusion with heterocyclic rings, and any further rearrangements of allobetulin compounds including ring opening, ring contraction and ring expansion reactions. In the last part, the most important biological activities of allobetulin derivatives are listed. One hundred and fifteen references are cited and the relevant literature is covered, starting in 1922 up to the end of 2010.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.