Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives

Molecules

Ionuţ Ledeţi¹  Ştefana Avram¹  Vasile Bercean³  Gabriela Vlase²  Titus Vlase²  Adriana Ledeţi¹  Istvan Zupko⁴  Marius Mioc¹  Lenuᘺ-Maria Şuta¹  Codruᘺ Şoica¹  Cristina Dehelean¹ 

[1] Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania;Research Centre for Thermal Analysis in Environmental Problems, West University of Timişoara, 300115 Timisoara, Romania;;Faculty of Industrial Chemistry and Environmental Engineering, Politehnica University Timişoara, 6 Carol Telbisz, 300001 Timisoara, RomaniaDepartment of Pharmacodynamics and Biopharmacy, University of Szeged, 6 Eotvos Str., H-6720 Szeged, Hungary;

关键词: betulonic acid derivatives;    triterpene;    thermal analysis;    synthesis;    biological activity;    MTT assay;   

DOI  :  10.3390/molecules201219876

来源: mdpi

【 摘 要 】

Betulonic acid belongs to the pentacyclic triterpenic derivative class and can be obtained through the selective oxidation of betulin. In this study we set obtaining several functionalized derivatives of this compound by its condensation with several amino compounds such as aminoguanidine, hydroxylamine, n-butylamine and thiosemicarbazide as our goal. The functionalization of the parent compound led to several molecules with antiproliferative potential, the most promising being 3–2-carbamothioylhydrazonolup-20(29)-en-28-oic acid.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.