Chemical Screening Method for the Rapid Identification of Microbial Sources of Marine Invertebrate-Associated Metabolites

Marine Drugs

Fabrice Berrue¹  Sydnor T. Withers¹  Brad Haltli²  Jo Withers² 

[1] Department of Chemistry & Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PEI, Canada;

关键词: chemical screening;    coral-associated bacteria;    UPLC/MS;    gorgonian coral;   

DOI  :  10.3390/md9030369

来源: mdpi

【 摘 要 】

Marine invertebrates have proven to be a rich source of secondary metabolites. The growing recognition that marine microorganisms associated with invertebrate hosts are involved in the biosynthesis of secondary metabolites offers new alternatives for the discovery and development of marine natural products. However, the discovery of microorganisms producing secondary metabolites previously attributed to an invertebrate host poses a significant challenge. This study describes an efficient chemical screening method utilizing a 96-well plate-based bacterial cultivation strategy to identify and isolate microbial producers of marine invertebrate-associated metabolites.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.