Bioactive Pregnane Steroids from a South China Sea Gorgonian Carijoa sp.

Molecules

Hong-Ying Zhao²  Chang-Lun Shao²  Zhi-Yong Li¹  Lei Han²  Fei Cao² 

[1] Marine Biotechnology Laboratory, State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China;Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; E-Mails:

关键词: gorgonian coral;    Carijoa sp.;    pregnane steroid;    cytotoxicity;    antibacterial activity;   

DOI  :  10.3390/molecules18033458

来源: mdpi

【 摘 要 】

A new pregnane steroid, 1, and three known analogues 2–4, have been isolated from a gorgonian Carijoa sp. collected from the South China Sea. The planar structure and relative configuration of 1 were elucidated from comprehensive spectroscopic data. Its absolute configuration was determined by application of the modified Mosher method. Compounds 1, 3 and 4 exhibited cytotoxicity against the human hepatoma cell line Bel-7402, with IC₅₀ values of 9.33, 11.02 and 18.68 µM, respectively. Additionally, compound 1 exhibited promising antibacterial activity against Pseudomona puido, with a MIC value of 31 nM, which is approximately 5-fold more potent than ciprofloxacin (MIC = 156 nM).

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.