Molecules | |
Synthesis of Ginkgolic Acid Analogues and Evaluation of Their Molluscicidal Activity | |
Peng Zhang1  Jiahu Pan1  Wanxing Duan1  Xuedong Li1  Yao Zhang1  Yibiao Zhou1  Qingwu Jiang1  Zuohua Mao1  | |
[1] 1School of Pharmacy, Fudan University, Shanghai 201203, China 2Shanghai Medical College, Fudan University, Shanghai 200032, China 3School of Public Health, Fudan University, Shanghai 200032, China | |
关键词: ginkgolic acid analogues; synthesis; molluscicidal activity; snail; schistosomiasis; | |
DOI : 10.3390/molecules16054059 | |
来源: mdpi | |
【 摘 要 】
Based on the molluscicidal activity of ginkgolic acids (GAs) isolated from Ginkgo biloba L, a series of Z/E isomers of GA analogues were prepared and evaluated for their molluscicidal activities against the host snail Oncomelania hupensis. The results and analysis of the structure-activity relationship revealed that the E-isomers showed better molluscicidal activities than their Z-isomers. Molluscicidal activities decreased with the shortening of the alkenyl chain lengths.
【 授权许可】
CC BY
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190049742ZK.pdf | 195KB | download |