Synthesis of Ginkgolic Acid Analogues and Evaluation of Their Molluscicidal Activity

Molecules

Peng Zhang¹  Jiahu Pan¹  Wanxing Duan¹  Xuedong Li¹  Yao Zhang¹  Yibiao Zhou¹  Qingwu Jiang¹  Zuohua Mao¹ 

[1] ¹School of Pharmacy, Fudan University, Shanghai 201203, China ²Shanghai Medical College, Fudan University, Shanghai 200032, China ³School of Public Health, Fudan University, Shanghai 200032, China

关键词: ginkgolic acid analogues;    synthesis;    molluscicidal activity;    snail;    schistosomiasis;   

DOI  :  10.3390/molecules16054059

来源: mdpi

【 摘 要 】

Based on the molluscicidal activity of ginkgolic acids (GAs) isolated from Ginkgo biloba L, a series of Z/E isomers of GA analogues were prepared and evaluated for their molluscicidal activities against the host snail Oncomelania hupensis. The results and analysis of the structure-activity relationship revealed that the E-isomers showed better molluscicidal activities than their Z-isomers. Molluscicidal activities decreased with the shortening of the alkenyl chain lengths.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.