Copper(I)-Catalyzed [ 3+ 2] Cycloaddition of 3-Azidoquinoline-2,4(1H,3H)-diones with Terminal Alkynes

Molecules

Stanislav Kafka¹  Sylvia Hauke¹  Arjana Salcinovic¹  Otto Soidinsalo¹  Damijana Urankar¹ 

[1] ¹Department of Chemistry, Faculty of Technology, Tomas Bata University in Zlin, Zlin 76272, Czech Republic

关键词: cycloaddition;    azides;    quinoline-2;    4(1H;    3H)-diones;    terminal alkynes;    1;    2;    3-triazoles;   

DOI  :  10.3390/molecules16054070

来源: mdpi

【 摘 要 】

3-Azidoquinoline-2,4(1H,3H)-diones 1, which are readily available from 4-hydroxyquinolin-2(1H)-ones 4 via 3-chloroquinoline-2,4(1H,3H)-diones 5, afford, in copper(I)-catalyzed [3 + 2] cycloaddition reaction with terminal acetylenes, 1,4-disubstituted 1,2,3-triazoles 3 in moderate to excellent yields. The structures of compounds 3 were confirmed by ¹H and ¹³C-NMR spectroscopy, combustion analyses and mass spectrometry.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.