An efficient synthesis of imidazo[2,1-b][1,3,4]thiadiazol-7-ium hydroxides by a one-pot, three-component reaction in water

Heterocyclic communications

article

Jabbar Khalafy¹  Nasser Etivand¹  Neda Khalillou¹ 

[1] Department of Organic Chemistry, Faculty of Chemistry, Urmia University

关键词: aryl glyoxal monohydrates;    5-ethyl-1;    3;    4-thiadiazol-2-amine;    green one-pot reaction;    imidazo[2;    1-b][1;    3;    4]thiadiazol-7-ium hydroxides;    quinoline-2;    4-diol;   

DOI  :  10.1515/hc-2018-0117

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

An improved synthesis of 2-ethyl-5-(2-hydroxy-4-oxoquinolin-3(4 H )-ylidene)-6-aryl-5,6-dihydroimidazo[2,1- b ][1,3,4]thiadiazol-7-ium hydroxide derivatives 4a–k via the reaction of aryl glyoxal monohydrates 1a–k , quinoline-2,4-diol 2 and 2-amino-[1,3,4]thiadiazole (3) in the presence of Et 3 N/sulfamic acid in H 2 O is described. This green protocol is characterized by the use of the readily available catalyst and reactants, short reaction times, operational simplicity and high yields of products. The structures of all compounds were characterized by 1 H NMR, 13 C NMR and Fourier-transform infrared (FT-IR) spectral data and microanalyses.

【 授权许可】

CC BY|CC BY-NC-ND