Heterocyclic communications | |
An efficient synthesis of imidazo[2,1-b][1,3,4]thiadiazol-7-ium hydroxides by a one-pot, three-component reaction in water | |
article | |
Jabbar Khalafy1  Nasser Etivand1  Neda Khalillou1  | |
[1] Department of Organic Chemistry, Faculty of Chemistry, Urmia University | |
关键词: aryl glyoxal monohydrates; 5-ethyl-1; 3; 4-thiadiazol-2-amine; green one-pot reaction; imidazo[2; 1-b][1; 3; 4]thiadiazol-7-ium hydroxides; quinoline-2; 4-diol; | |
DOI : 10.1515/hc-2018-0117 | |
学科分类:内科医学 | |
来源: De Gruyter | |
【 摘 要 】
An improved synthesis of 2-ethyl-5-(2-hydroxy-4-oxoquinolin-3(4 H )-ylidene)-6-aryl-5,6-dihydroimidazo[2,1- b ][1,3,4]thiadiazol-7-ium hydroxide derivatives 4a–k via the reaction of aryl glyoxal monohydrates 1a–k , quinoline-2,4-diol 2 and 2-amino-[1,3,4]thiadiazole (3) in the presence of Et 3 N/sulfamic acid in H 2 O is described. This green protocol is characterized by the use of the readily available catalyst and reactants, short reaction times, operational simplicity and high yields of products. The structures of all compounds were characterized by 1 H NMR, 13 C NMR and Fourier-transform infrared (FT-IR) spectral data and microanalyses.
【 授权许可】
CC BY|CC BY-NC-ND
【 预 览 】
Files | Size | Format | View |
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RO202107200002237ZK.pdf | 165KB | download |