Materials | |
Structural Consideration in Designing Organotin Polyethers to Arrest the Growth of Breast Cancer Cells |
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Charles E. Carraher1  Michael R. Roner2  Kimberly Shahi3  | |
[1] Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA; E-Mail:;Department of Biology, University of Texas Arlington, Arlington, TX 76019, USA;Department of Biological Sciences, University of North Texas, Denton, TX 76203, USA; E-Mail: | |
关键词: tin-containing polymers; cancer; breast cancer; organotin compounds; organotin polyethers; estrogen receptor positive breast cancer; estrogen-independent breast cancer; | |
DOI : 10.3390/ma4040801 | |
来源: mdpi | |
【 摘 要 】
The ability to inhibit cancer is inherent in organotin materials yet the structural relationships that regulate/direct this activity remains unknown. We measured antitumor activity using a matched pair of cell lines MDA-MB-231 cells that are estrogen-independent, estrogen receptor negative and MCF-7 cells, a cell line that is estrogen receptor (ER) positive. Those polyethers that contained a O-phenyl unit were able to significantly inhibit the non-estrogen sensitive cell line but were much less effective against the estrogen sensitive cell line; that is, the human breast cancer cell line MDA-MB-231 showed better test results for polymers derived from diols containing the O-phenyl moiety than the breast cancer cell line MCF-7, a well-characterized estrogen receptor positive control cell line. Those polyethers that did not contain the O-phenyl unit inhibited both cell lines approximately the same. The differential activity of the O-phenyl-containing polyethers is likely due to the estrogen-sensitive cells combining with some of the organotin polyethers minimizing their ability to inhibit cell growth.
【 授权许可】
CC BY
© 2011 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190049705ZK.pdf | 231KB | download |