Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba

Molecules

Hai-Xue Kuang¹  Hong-Wei Li¹  Qiu-Hong Wang¹  Bing-You Yang¹  Zhi-Bin Wang¹ 

[1] Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China

关键词: Sanguisorba tenuifolia var. Alba;    triterpenoids;    α-glucosidase inhibitory activity;    diabetes mellitus;   

DOI  :  10.3390/molecules16064642

来源: mdpi

【 摘 要 】

The ethyl acetate soluble fraction from the roots of Sanguisorba tenuifolia was found to have a hypoglucemic effect in alloxan-induced diabetic rats. Two new triterpenoids, identified as 2-oxo-3β,19α-dihydroxyolean-12-en-28-oic acid β-D-gluco-pyranosyl ester (1) and 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid β-D-glucopyranosyl ester (4) were isolated from this fraction, along with thirteen known triterpenoids. Their structures were elucidated by chemical and spectroscopic methods. All these compounds demonstrated inhibitory activities against α-glucosidase with IC₅₀ values in the 0.62-3.62 mM range.

【 授权许可】

CC BY   
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