Application of Magnetic Nanoparticles to Gene Delivery

International Journal of Molecular Sciences

Daisuke Kami²  Shogo Takeda¹  Yoko Itakura²  Satoshi Gojo²  Masatoshi Watanabe¹ 

[1] Laboratory for Medical Engineering, Division of Materials and Chemical Engineering, Yokohama National University, 79-1 Tokiwadai, Hodogaya-ku, Yokohama 240-8501, Japan; E-Mails:;Research Team for Vascular Medicine, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan; E-Mails:

关键词: magnetic nanoparticles;    Magnetofection;    gene delivery;    polyethylenimine;   

DOI  :  10.3390/ijms12063705

来源: mdpi

【 摘 要 】

Nanoparticle technology is being incorporated into many areas of molecular science and biomedicine. Because nanoparticles are small enough to enter almost all areas of the body, including the circulatory system and cells, they have been and continue to be exploited for basic biomedical research as well as clinical diagnostic and therapeutic applications. For example, nanoparticles hold great promise for enabling gene therapy to reach its full potential by facilitating targeted delivery of DNA into tissues and cells. Substantial progress has been made in binding DNA to nanoparticles and controlling the behavior of these complexes. In this article, we review research on binding DNAs to nanoparticles as well as our latest study on non-viral gene delivery using polyethylenimine-coated magnetic nanoparticles.

【 授权许可】

CC BY   
© 2011 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.