Viruses | |
Move or Die: the Fate of the Tax Oncoprotein of HTLV-1 | |
Julie Lodewick1  Isabelle Lamsoul1  | |
[1] 1Institut de Recherches Microbiologiques J-M Wiame, Université Libre de Bruxelles, Avenue E. Gryson 1, B-1070 Bruxelles, Belgium | |
关键词: HTLV-1; Tax; retrovirus; signal transduction; NF-kB; nuclear bodies; intracellular trafficking; posttranslational modifications; leukemia; | |
DOI : 10.3390/v3060829 | |
来源: mdpi | |
【 摘 要 】
The HTLV-1 Tax protein both activates viral replication and is involved in HTLV-1-mediated transformation of T lymphocytes. The transforming properties of Tax include altering the expression of select cellular genes via activation of cellular pathways and perturbation of both cell cycle control mechanisms and apoptotic signals. The recent discovery that Tax undergoes a hierarchical sequence of posttranslational modifications that control its intracellular localization provides provocative insights into the mechanisms regulating Tax transcriptional and transforming activities.
【 授权许可】
CC BY
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
【 预 览 】
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