Catalytic Synthesis of α-Oxoketene S,S-Acetals in a Wet Ionic Liquid [Bmim]Cl/H2O Homogeneous System

Molecules

Ping Yu¹  Yuangang Zu¹  Yujie Fu¹ 

[1] ¹Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, China ²Engineering Research Center of Forest Bio-preparation, Ministry of Education, Northeast Forestry University, Harbin 150040, China ³Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Mainz 55128, Germany

关键词: 1;    3-dicarbonyl compounds;    α-oxoketene S;    S-acetals;    [Bmim]Cl;    water;   

DOI  :  10.3390/molecules16064500

来源: mdpi

【 摘 要 】

A clean, practical and environmentally friendly synthesis in a homogeneous system has been developed for α-oxoketene S,S-acetals. A mixture of [Bmim]Cl and water was used as medium. The best economical and practical molar ratio of [Bmim]Cl to substrate was 4 to 1. With various types of 1,3-dicarbonyl compounds as substrate, the corresponding α-oxoketene S,S-acetals have been prepared under mild reaction conditions with yields of 53–74% after purification with silica gel column. [Bmim]Cl/water can be recycled several times.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.