Iminoiodane- and Brønsted Base-Mediated Cross Dehydrogenative Coupling of Cyclic Ethers with 1,3-Dicarbonyl Compounds

Molecules

Ciputra Tejo¹  Xiao Rong Sim¹  Bo Ra Lee³  Benjamin James Ayers¹  Chung-Hang Leung²  Dik-Lung Ma⁴  Philip Wai Hong Chan³ 

[1] Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore; E-Mails:;State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China; E-Mail:;School of Chemistry, Monash University, Clayton, Victoria 3800, Australia; E-Mail:;Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China; E-Mail:

关键词: C–C bond formation;    cross dehydrogenation coupling;    1;    3-dicarbonyl compounds;    iminoiodanes;    metal-free catalysis;   

DOI  :  10.3390/molecules200713336

来源: mdpi

【 摘 要 】

A one-pot, two-step approach to prepare 2-tetrahydrofuran and -pyran substituted 1,3-dicarbonyl compounds by PhI=NTs-mediated amination/Brønsted base-catalyzed cross dehydrogenative coupling (CDC) reaction of the cyclic ether and 1,3-dicarbonyl derivative under mild conditions is reported. The reaction is compatible with a variety of cyclic ethers and 1,3-dicarbonyl compounds, affording the corresponding coupled products in moderate to good yields of up to 80% over two steps.

【 授权许可】

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