Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei

Marine Drugs

Simona De Marino²  Carmen Festa²  Maria Valeria D𠆚uria²  Thierry Cresteil¹  Cecile Debitus³ 

[1] Natural Substances Institute, la Terrasse Street, 91198 Gif sur Yvette Cedex, France; E-Mail:;Department of Chemistry of Natural Compounds, University of Naples, “Federico II”, via D. Montesano 49, 80131 Napoli, Italy; E-Mails:;Polynesian Research Center on Island Biodiversity, UMR 7138 CNRS, B.P. 529, 98713 Papeete, Tahiti, French Polynesia, France; E-Mail:

关键词: marine cytotoxin;    swinholide J;    Theonella swinhoei;   

DOI  :  10.3390/md9061133

来源: mdpi

【 摘 要 】

In our ongoing search for new pharmacologically active leads from Solomon organisms, we have examined the sponge Theonella swinhoei. Herein we report the isolation and structure elucidation of swinholide A (1) and one new macrolide, swinholide J (2). Swinholide J is an unprecedented asymmetric 44-membered dilactone with an epoxide functionality in half of the molecule. The structural determination was based on extensive interpretation of high-field NMR spectra and HRESIMS data. Swinholide J displayed potent in vitro cytotoxicity against KB cells (human nasopharynx cancer) with an IC₅₀ value of 6 nM.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.