Solomonsterol A, a Marine Pregnane-X-Receptor Agonist, Attenuates Inflammation and Immune Dysfunction in a Mouse Model of Arthritis

Marine Drugs

Andrea Mencarelli²  Claudio D𠆚more²  Barbara Renga²  Sabrina Cipriani²  Adriana Carino²  Valentina Sepe¹  Elisa Perissutti¹  Maria Valeria D𠆚uria¹  Angela Zampella¹  Eleonora Distrutti³ 

[1] Department of Pharmacy, University of Naples “Federico II”, D. Montesano Street, 49, Naples 80131, Italy; E-Mails:;Department of Experimental and Clinical Medicine, University of Perugia, Gambuli Street, S. Andrea delle Fratte, Perugia 06132, Italy; E-Mails:;University and City Hospital of Perugia, Perugia 06100, Italy; E-Mail:

关键词: marine sponge;    Theonella swinhoei;    rheumatoid arthritis;    inflammation;    pregnane X receptor (PXR);    solomonsterol A;   

DOI  :  10.3390/md12010036

来源: mdpi

【 摘 要 】

In the present study we provide evidence that solomonsterol A, a selective pregnane X receptor (PXR) agonist isolated from the marine sponge Theonella swinhoei, exerts anti-inflammatory activity and attenuates systemic inflammation and immune dysfunction in a mouse model of rheumatoid arthritis. Solomonsterol A was effective in protecting against the development of arthritis induced by injecting transgenic mice harboring a humanized PXR, with anti-collagen antibodies (CAIA) with beneficial effects on joint histopathology and local inflammatory response reducing the expression of inflammatory markers (TNFα, IFNγ and IL-17 and chemokines MIP1α and RANTES) in draining lymph nodes. Solomonsterol A rescued mice from systemic inflammation were assessed by measuring arthritis score, CRP and cytokines in the blood. In summary, the present study provides a molecular basis for the regulation of systemic local and systemic immunity by PXR agonists.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.