Zorrimidazolone, a Bioactive Alkaloid from the Non-Indigenous Mediterranean Stolidobranch Polyandrocarpa zorritensis

Marine Drugs

Anna Aiello²  Ernesto Fattorusso²  Concetta Imperatore²  Carlo Irace¹  Paolo Luciano³  Marialuisa Menna²  Rita Santamaria¹ 

[1] Department of Experimental Pharmacology, University of Napoli “Federico II”, Via D. Montesano 49, Napoli 80131, Italy; E-Mail:;The NeaNat Group, Department of Chemistry of Natural Products, University of Napoli “Federico II”, Via D. Montesano 49, Napoli 80131, Italy; E-Mails:;C.S.I.A.S. (Interdepartmental Service Center for Spectroscopic Analysis), University of Napoli “Federico II”, Via D. Montesano 49, Napoli 80131, Italy; E-Mail:

关键词: ascidians;    natural products;    alkaloids;    bioactive molecules;    cytotoxic activity;   

DOI  :  10.3390/md9061157

来源: mdpi

【 摘 要 】

Chemical analysis of the Mediterranean ascidian Polyandrocarpa zorritensis (Van Name 1931) resulted in the isolation of a series of molecules including two monoindole alkaloids, 3-indolylglyoxylic acid (3) and its methyl ester (4), 4-hydroxy-3-methoxyphenylglyoxylic acid methyl ester (1) and a new alkaloid we named zorrimidazolone (2). The structure of the novel compound 2 has been elucidated by spectroscopic analysis and bioactivity of all compounds has been investigated. Zorrimidazolone (2) showed a modest cytotoxic activity against C6 rat glioma cell line.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.