Micro- and Nanoengineering Approaches to Control Stem Cell-Biomaterial Interactions

Journal of Functional Biomaterials

Alireza Dolatshahi-Pirouz²  Mehdi Nikkhah²  Kristian Kolind¹  Mehmet R. Dokmeci² 

[1] Interdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000 Aarhus C, Denmark;E-Mail:;Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital,Harvard Medical School, Boston, MA 02139, USA; E-Mails:

关键词: micro- and nanotopography;    microwells;    microarrays;    embryonic and adult stem cells;    stem cell therapy;   

DOI  :  10.3390/jfb2030088

来源: mdpi

【 摘 要 】

As our population ages, there is a greater need for a suitable supply of engineered tissues to address a range of debilitating ailments. Stem cell based therapies are envisioned to meet this emerging need. Despite significant progress in controlling stem cell differentiation, it is still difficult to engineer human tissue constructs for transplantation. Recent advances in micro- and nanofabrication techniques have enabled the design of more biomimetic biomaterials that may be used to direct the fate of stem cells. These biomaterials could have a significant impact on the next generation of stem cell based therapies. Here, we highlight the recent progress made by micro- and nanoengineering techniques in the biomaterials field in the context of directing stem cell differentiation. Particular attention is given to the effect of surface topography, chemistry, mechanics and micro- and nanopatterns on the differentiation of embryonic, mesenchymal and neural stem cells.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.