Biocatalytic Resolution of Enantiomeric Mixtures of 1-Aminoethanephosphonic Acid

Molecules

Małgorzata Brzezińska-Rodak¹  Magdalena Klimek-Ochab¹  Ewa Żymańczyk-Duda¹ 

[1] Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wroclaw, Poland

关键词: aminophosphonic acid;    fungi;    resolution of racemic mixture;   

DOI  :  10.3390/molecules16075896

来源: mdpi

【 摘 要 】

Several fungal strains, namely Bauveria bassiana, Cuninghamella echinulata, Aspergillus fumigatus, Penicillium crustosum and Cladosporium herbarum, were used as biocatalysts to resolve racemic mixtures of 1-aminoethanephosphonic acid using L/D amino acid oxidase activity. The course of reaction was analyzed by ³¹P-NMR in the presence of cyclodextrin used as chiral discriminating agent. The best result (42% e.e of R-isomer) was obtained with a strain of Cuninghamella echinulata.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.