International Journal of Molecular Sciences | |
Identification and Categorization of Liver Toxicity Markers Induced by a Related Pair of Drugs | |
Ching-Wei Chang1  Frederick A. Beland4  Wade M. Hines3  James C. Fuscoe2  Tao Han2  | |
[1] Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA; E-Mail:;Division of Systems Biology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA; E-Mails:;BG Medicine, Inc. Waltham, MA 02451, USA; E-Mail:;Division of Biochemical Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA; E-Mail: | |
关键词: liver toxicity; biomarker; genomic; personalized medicine; population heterogeneity; entacapone; tolcapone; | |
DOI : 10.3390/ijms12074609 | |
来源: mdpi | |
【 摘 要 】
Drug-induced liver injury (DILI) is the primary adverse event that results in the withdrawal of drugs from the market and a frequent reason for the failure of drug candidates in the pre-clinical or clinical phases of drug development. This paper presents an approach for identifying potential liver toxicity genomic biomarkers from a liver toxicity biomarker study involving the paired compounds entacapone (“non-liver toxic drug”) and tolcapone (“hepatotoxic drug”). Molecular analysis of the rat liver and plasma samples, combined with statistical analysis, revealed many similarities and differences between the
【 授权许可】
CC BY
© 2011 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190048882ZK.pdf | 387KB | download |