In Vitro Activity of Plant Extracts and Alkaloids against Clinical Isolates of Extended-Spectrum b-Lactamase (ESBL)-Producing Strains

Molecules

Guo-Ying Zuo¹  Fan-Yan Meng¹  Jun Han¹  Xiao-Yan Hao¹  Gen-Chun Wang¹  Yun-Ling Zhang¹ 

[1] ¹Research Center for Natural Medicines, Kunming General Hospital, PLA, Kunming 650032, China ²School of Pharmacy, Guiyang Medical College, Guiyang 550004, China ³School of Basic Medicine, Yunnan Traditional Chinese Medical College, Kunming 650500, China

关键词: antibacterial plant extracts;    ESBLs;    8-hydroxydihydrosanguinarine;    8-hydroxydihydrochelerythrine;   

DOI  :  10.3390/molecules16075453

来源: mdpi

【 摘 要 】

The antibacterial activity of 80% ethanol extracts of 10 medicinal plants collected in Yunnan (Southwest China), was tested against clinical isolates of extended-spectrum b-lactamase (ESBL)-producing strains. Their MIC values ranged between 1.56–12.50 mg/mL. The most active plant extract was Chelidonium majus L. (MIC = 1.56 mg/mL). Two potent isoquinoline alkaloids, 8-hydroxydihydrosanguinarine and 8-hydroxydihydrochelerythrine, were identified as the major active principles through bioassay-guided fractionation and identification of the active ethyl acetate fraction from C. majus, with minimum MIC/MBC values of 15.63/62.50 mg/mL.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.