Genetic Risk for Alcoholic Chronic Pancreatitis

International Journal of Environmental Research and Public Health

Marianges Zadrozny Gouvສ da Costa¹  Dulce Reis Guarita²  Suzane Kioko Ono-Nita²  Denise Cerqueira Paranaguá-Vezozzo²  Guilherme Eduardo Gon๺lves Felga²  Martha Regina Arcon Pedroso²  Marcelo Moreira Tavares de Souza²  Paulo Dominguez Nasser²  Camila da Silva Ferreira² 

[1] Department of Gastroenterology, School of Medicine, University of São Paulo, São Paulo 05403-000, Brazil;

关键词: pancreatic diseases;    alcoholism;    genetics;    cationic trypsinogen;    cystic fibrosis transmembrane conductance regulator;    serine protease inhibitor kazal type 1;    chymotrypsin C;   

DOI  :  10.3390/ijerph8072747

来源: mdpi

【 摘 要 】

In recent years many studies have examined the genetic predisposition to pancreatic diseases. Pancreatic disease of an alcoholic etiology was determined to be a multi-factorial disease, where environmental factors interact with the genetic profile of the individual. In this review we discuss the main results from studies examining the frequency of genetic mutations in alcoholic chronic pancreatitis.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland