Antimicrobial and Antioxidant Activities of New Metal Complexes Derived from 3-Aminocoumarin

Molecules

Abdul Amir H. Kadhum¹  Abu Bakar Mohamad¹  Ahmed A. Al-Amiery¹ 

[1] ¹Department of Chemical and Process Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, Bangi, Selangor 43600, Malaysia ²Biotechnology Division, Applied Science Department, University of Technology, Baghdad 10066, Iraq

关键词: 3-aminocoumarin;    antimicrobial;    complexes;    DPPH;    scavenging;   

DOI  :  10.3390/molecules16086969

来源: mdpi

【 摘 要 】

3-Aminocoumarin (L) has been synthesized and used as a ligand for the formation of Cr(III), Ni(II), and Cu(II) complexes. The chemical structures were characterized using different spectroscopic methods. The elemental analyses revealed that the complexes where M=Ni(II) and Cu(II) have the general formulae [ML₂Cl₂], while the Cr(III) complex has the formula [CrL₂Cl₂]Cl. The molar conductance data reveal that all the metal chelates, except the Cr(III) one, are non-electrolytes. From the magnetic and UV-Visible spectra, it is found that these complexes have octahedral structures. The stability for the prepared complexes was studied theoretically using Density Function Theory. The total energy for the complexes was calculated and it was shown that the copper complex is the most stable one. Complexes were tested against selected types of microbial organisms and showed significant activities. The free radical scavenging activity of metal complexes have been determined by measuring their interaction with the stable free radical DPPH and all the compounds have shown encouraging antioxidant activities.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.