Epigenetics: New Questions on the Response to Hypoxia

International Journal of Molecular Sciences

Joel I. Perez-Perri¹  Julieta M. Acevedo¹ 

[1] Instituto Leloir, Patricias Argentinas 435, Buenos Aires C1405BWE, Argentina; E-Mails:

关键词: HIF;    oxygen;    stress;    chromatin;    histone;    jumonji;   

DOI  :  10.3390/ijms12074705

来源: mdpi

【 摘 要 】

Reduction in oxygen levels below normal concentrations plays important roles in different normal and pathological conditions, such as development, tumorigenesis, chronic kidney disease and stroke. Organisms exposed to hypoxia trigger changes at both cellular and systemic levels to recover oxygen homeostasis. Most of these processes are mediated by Hypoxia Inducible Factors, HIFs, a family of transcription factors that directly induce the expression of several hundred genes in mammalian cells. Although different aspects of HIF regulation are well known, it is still unclear by which precise mechanism HIFs activate transcription of their target genes. Concomitantly, hypoxia provokes a dramatic decrease of general transcription that seems to rely in part on epigenetic changes through a poorly understood mechanism. In this review we discuss the current knowledge on chromatin changes involved in HIF dependent gene activation, as well as on other epigenetic changes, not necessarily linked to HIF that take place under hypoxic conditions.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.