Aberrant Signaling Pathways in Glioma

Cancers

Mitsutoshi Nakada¹  Daisuke Kita¹  Takuya Watanabe¹  Yutaka Hayashi¹  Lei Teng¹  Ilya V. Pyko¹ 

[1] Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa 920-8641, Japan; E-Mails:

关键词: glioblastoma;    signaling;    proliferation;    invasion;    angiogenesis;    molecular target;   

DOI  :  10.3390/cancers3033242

来源: mdpi

【 摘 要 】

Glioblastoma multiforme (GBM), a WHO grade IV malignant glioma, is the most common and lethal primary brain tumor in adults; few treatments are available. Median survival rates range from 12–15 months. The biological characteristics of this tumor are exemplified by prominent proliferation, active invasiveness, and rich angiogenesis. This is mainly due to highly deregulated signaling pathways in the tumor. Studies of these signaling pathways have greatly increased our understanding of the biology and clinical behavior of GBM. An integrated view of signal transduction will provide a more useful approach in designing novel therapies for this devastating disease. In this review, we summarize the current understanding of GBM signaling pathways with a focus on potential molecular targets for anti-signaling molecular therapies.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.