Converging Strategies in Expression of Human Complex Retroviruses

Viruses

Ilaria Cavallari¹  Francesca Rende¹  Donna M. D'Agostino¹ 

[1] ¹Department of Oncology and Surgical Sciences, University of Padova, Via Gattamelata 64, I-35128 Padova, Italy ²Istituto Oncologico Veneto-IRCCS, I-35128 Padova, Italy ^†These authors contributed equally.

关键词: HTLV-1;    Rex;    leukemia;   

DOI  :  10.3390/v3081395

来源: mdpi

【 摘 要 】

The discovery of human retroviruses in the early 1980s revealed the existence of viral-encoded non-structural genes that were not evident in previously described animal retroviruses. Based on the absence or presence of these additional genes retroviruses were classified as ‘simple’ and ‘complex’, respectively. Expression of most of these extra genes is achieved through the generation of alternatively spliced mRNAs. The present review summarizes the genetic organization and expression strategies of human complex retroviruses and highlights the converging mechanisms controlling their life cycles.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.