Pharmaceutics | |
Effect of Penetration Enhancer Containing Vesicles on the Percutaneous Delivery of Quercetin through New Born Pig Skin | |
Maura Chessa1  Carla Caddeo1  Donatella Valenti1  Maria Manconi2  Chiara Sinico1  | |
[1] id="af1-pharmaceutics-03-00497">Dipartimento Farmaco Chimico Tecnologico, University of Cagliari, Via Ospedale 72, Cagliari, Ita | |
关键词: liposome; quercetin; penetration enhancer; skin permeation; rheology; confocal laser scanning microscopy; bioflavonoid; | |
DOI : 10.3390/pharmaceutics3030497 | |
来源: mdpi | |
【 摘 要 】
Quercetin (3,3′,4′,5,7-pentahydroxyflavone) exerts multiple pharmacological effects: anti-oxidant activity, induction of apoptosis, modulation of cell cycle, anti-mutagenesis, and anti-inflammatory effect. In topical formulations quercetin inhibits oxidative skin damage and the inflammatory processes induced by solar UV radiation. In this work, quercetin (2 mg/mL) was loaded in vesicular Penetration Enhancer containing Vesicles (PEVs), prepared using a mixture of lipids (Phospholipon® 50, P50) and one of four selected hydrophilic penetration enhancers: Transcutol® P, propylene glycol, polyethylene glycol 400, and Labrasol® at the same concentration (40% of water phase). Photon Correlation Spectroscopy results showed a mean diameter of drug loaded vesicles in the range 80–220 nm. All formulations showed a negative surface charge and incorporation efficiency in the range 48–75%. Transmission Electron Microscopy confirmed that size and morphology varied as a function of the used penetration enhancer. The influence of PEVs on
【 授权许可】
CC BY
© 2011 by the authors; licensee MDPI, Basel, Switzerland.
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