Identification of the Antibacterial Compound Produced by the Marine Epiphytic Bacterium Pseudovibrio sp. D323 and Related Sponge-Associated Bacteria

Marine Drugs

Anahit Penesyan²  Jan Tebben¹  Matthew Lee²  Torsten Thomas²  Staffan Kjelleberg²  Tilmann Harder¹ 

[1] School of Biological, Earth and Environmental Sciences and Centre for Marine Bio-Innovation, University of New South Wales, Sydney 2052, New South Wales, Australia; E-Mails:;School of Biotechnology and Biomolecular Sciences and Centre for Marine Bio-Innovation, University of New South Wales, Sydney 2052, New South Wales, Australia; E-Mails:

关键词: marine bacteria;    bioactive;    antimicrobial;    symbiosis;    tropodithietic acid;   

DOI  :  10.3390/md9081391

来源: mdpi

【 摘 要 】

Surface-associated marine bacteria often produce secondary metabolites with antagonistic activities. In this study, tropodithietic acid (TDA) was identified to be responsible for the antibacterial activity of the marine epiphytic bacterium Pseudovibrio sp. D323 and related strains. Phenol was also produced by these bacteria but was not directly related to the antibacterial activity. TDA was shown to effectively inhibit a range of marine bacteria from various phylogenetic groups. However TDA-producers themselves were resistant and are likely to possess resistance mechanism preventing autoinhibition. We propose that TDA in isolate D323 and related eukaryote-associated bacteria plays a role in defending the host organism against unwanted microbial colonisation and, possibly, bacterial pathogens.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.